Calcium blockers improve effect of chemotherapy in pancreatic cancer.

Dr Leszek Kraj, a colleague from our department, has just presented results of a new very interesting study during the 2017 Annual Meeting of ASCO (American Society of Clinical Oncology). The study analyzed the outcomes of patients with pancreatic cancer. The pancreatic cancer has very bad prognosis. They analyzed the outcomes of patients with this cancer treated with chemotherapy and with calcium blockers (because of hypertension). There is a hint from laboratory trials that calcium blockers might improve the cytotoxic action of chemotherapy against cancer cells by blocking the cell pumps that are dependent on calcium and remove the drug from inside the cell. Once dr Kraj compared the group of 380 patients with pancreatic cancer who received the chemotherapy and calcium blocker with over 4000 of the patients treated with just chemotherapy the differences were more than evident. the calcium blocker had over double survival at 2 years (24% vs 11%). This is trully amazing and hopefully will lead to improved survival in this cancer. Congratulations on great work!

The abstract can be found here:

http://abstracts.asco.org/199/AbstView_199_187607.html

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Lecture – Stem cells in neurology

There is a new lecture online on the use of stem cells in neurology.

Download: 2017 Komórki macierzyste dla neurologów online

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“Lame will walk” – GREAT NEWS FOR CIDP PATIENTS on EBMT 2017 – update on autoimmune diseases.

I have just returned from the EBMT 2017 conference. I have met with most prominent world scientist in field of HSCT – and I am truly amazed by the results that were presented. Here are the most important observations:

  1. CIDP in Chicago – dr Burt presented amazing results of CIDP HSCT trial from Chicago. The publication is pending… but „lame will walk” seems to be the case here (and those youtube videos do not lie). JUST TO GIVE YOU ONE SIMPLE NUMBER: pre HSCT 30% CIDP patients could walk without aid (and 25% were on wheel chair) – 5 years post HSCT 80% needed no assist in walking and NONE were on wheelchair – simply AMAZING. I just hope that neurologists will send their patients for HSCT as soon as they get to read that publication.
  2. MS – dr Atkins shared some insights from his Lancet paper from 2016 (http://thelancet.com/journals/laneur/article/PIIS1474-4422(08)70138-8/fulltext) – EDSS after HSCT did not progress after 2 years have passed from transplantation – in the timeframe of 13 years of post HSCT observation. In his study 40% of patients has sustainded EDSS improvement.
  3. SSc – the big news – this is the first autoimmune disease that reached level „I” of recommendations for HSCT – what does that mean? – the HSCT just becomes the standard treatment of progressive form of this disease – the guidelines should be published soon. The MS status in guidelines is also about to change…
  4. Breast cancer – the addition of HSCT into treatment of triple negative form of breast cancer improves greatly the survival of patients. This is not autoimmune disease but the results are also very intriguing.

 

I had a presentation on new clinical trial on central line infection prevention and use of different forms of G-CSF in mobilization.

 

Summarizing: I am very happy with the progress. Now we have to wait for HSCT to become a level “I” option in Multiple Sclerosis. CIDP and Systemic Slerosis patients finally will get option of curative treatment.

 

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No benefit of cancer screening

I wrote this post over a year ago but forgot to post it. Interesting study.

 

There is an interesting publication in BMJ on cancer screening. Although the cancer screening dose reduce the mortality from the specific cancer it does not have influence on overall mortality. This is quite interesting to read:

 

The link:

http://www.bmj.com/content/352/bmj.h6080

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Great story of the first bone marrow transplants

Nice story of first bone marrow transplants:

http://www.signalsblog.ca/the-story-of-the-first-bone-marrow-transplant/

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Classic work – Thomas and Storb and bone marrow harvest

Recently I have reviewed the work by pioneers of bone marrow transplantation by Thomas and Storb – great publication and it gives a nice perspective on what we do today. You can read it here

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First Clinical Application of Talen Engineered Universal CAR19 T Cells in B-ALL

The title says it all – to read more about this interesting concept of creating “of the shell” cell product read here: http://www.bloodjournal.org/content/126/23/2046

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Very interesting news – Post transplant cyclophosphamide as only imunosupression in bone marrow transplantation

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Very interesting study to download here: http://ascopubs.org/doi/full/10.1200/JCO.2013.54.0625

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English Division at MUW – new page

I have reorganized the English Division informations on the page. They can be accessed at:

https://emiliansnarski.wordpress.com/english/students-2/

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Should the donor meet the recipient

The Polish TV reporter Aneta Gracjana Mierzwa has just made a short document on donor and recipient of bone marrow transplantation. Recently Polish health ministry announced official statement and interpretation of current law that forbids donor and recipient relations. However, you cannot forbid two people to get to know each other if they want to, also you cannot forbid the donors and patients to use their names if they want to promote the idea of stem cell donations as we all have right to use our personal data for this purposes. The movie can be seen here: link to the movie

 

 

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