“Lame will walk” – GREAT NEWS FOR CIDP PATIENTS on EBMT 2017 – update on autoimmune diseases.

I have just returned from the EBMT 2017 conference. I have met with most prominent world scientist in field of HSCT – and I am truly amazed by the results that were presented. Here are the most important observations:

  1. CIDP in Chicago – dr Burt presented amazing results of CIDP HSCT trial from Chicago. The publication is pending… but „lame will walk” seems to be the case here (and those youtube videos do not lie). JUST TO GIVE YOU ONE SIMPLE NUMBER: pre HSCT 30% CIDP patients could walk without aid (and 25% were on wheel chair) – 5 years post HSCT 80% needed no assist in walking and NONE were on wheelchair – simply AMAZING. I just hope that neurologists will send their patients for HSCT as soon as they get to read that publication.
  2. MS – dr Atkins shared some insights from his Lancet paper from 2016 (http://thelancet.com/journals/laneur/article/PIIS1474-4422(08)70138-8/fulltext) – EDSS after HSCT did not progress after 2 years have passed from transplantation – in the timeframe of 13 years of post HSCT observation. In his study 40% of patients has sustainded EDSS improvement.
  3. SSc – the big news – this is the first autoimmune disease that reached level „I” of recommendations for HSCT – what does that mean? – the HSCT just becomes the standard treatment of progressive form of this disease – the guidelines should be published soon. The MS status in guidelines is also about to change…
  4. Breast cancer – the addition of HSCT into treatment of triple negative form of breast cancer improves greatly the survival of patients. This is not autoimmune disease but the results are also very intriguing.

 

I had a presentation on new clinical trial on central line infection prevention and use of different forms of G-CSF in mobilization.

 

Summarizing: I am very happy with the progress. Now we have to wait for HSCT to become a level “I” option in Multiple Sclerosis. CIDP and Systemic Slerosis patients finally will get option of curative treatment.

 

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No benefit of cancer screening

I wrote this post over a year ago but forgot to post it. Interesting study.

 

There is an interesting publication in BMJ on cancer screening. Although the cancer screening dose reduce the mortality from the specific cancer it does not have influence on overall mortality. This is quite interesting to read:

 

The link:

http://www.bmj.com/content/352/bmj.h6080

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Great story of the first bone marrow transplants

Nice story of first bone marrow transplants:

http://www.signalsblog.ca/the-story-of-the-first-bone-marrow-transplant/

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Classic work – Thomas and Storb and bone marrow harvest

Recently I have reviewed the work by pioneers of bone marrow transplantation by Thomas and Storb – great publication and it gives a nice perspective on what we do today. You can read it here

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First Clinical Application of Talen Engineered Universal CAR19 T Cells in B-ALL

The title says it all – to read more about this interesting concept of creating “of the shell” cell product read here: http://www.bloodjournal.org/content/126/23/2046

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Very interesting news – Post transplant cyclophosphamide as only imunosupression in bone marrow transplantation

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Very interesting study to download here: http://ascopubs.org/doi/full/10.1200/JCO.2013.54.0625

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English Division at MUW – new page

I have reorganized the English Division informations on the page. They can be accessed at:

https://emiliansnarski.wordpress.com/english/students-2/

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Should the donor meet the recipient

The Polish TV reporter Aneta Gracjana Mierzwa has just made a short document on donor and recipient of bone marrow transplantation. Recently Polish health ministry announced official statement and interpretation of current law that forbids donor and recipient relations. However, you cannot forbid two people to get to know each other if they want to, also you cannot forbid the donors and patients to use their names if they want to promote the idea of stem cell donations as we all have right to use our personal data for this purposes. The movie can be seen here: link to the movie

 

 

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Preventing central line infections – lecture at EBMT Nurses Group International Study Day Gothenburg/Sweden

Today I had a pleasure to have a lecture on practices aiming at reduction of central line infections in HSCT patient – including the topic of family participation. The lecture as always is avaliabale on line: download

 

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Oncology – future trends in care

The new, refreshed oncology seminar for English Division Students can be downloaded here.

 

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