Lymphocytes against leukemia – are we there finally?

I have posted on this since 2011 but now the revolution in therapy of leukemia approaches. The team of the University of Pennsylvania just published a new publication in NEJM. In short, they modify the patients’ lymphocytes to kill leukemic cells … and it works. The achieved the amazing 90% of remission rates in kids and adults with ALL – the patients with relapse after HSCT – the population with 100% mortality to leukemia which is normally not responsive anymore to chemotherapy. My question is what would happen if we apply this to the patients not after unsuccessful HSCT but instead any HSCT. The answer to this question might dramatically change the way we treat leukemia.

PS What about AML which is a major leukemia in adults? The same group published some promising results in animal model of AML.

Advertisements
This entry was posted in Uncategorized. Bookmark the permalink.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s