Lymphocytes against leukemia – are we there finally?

I have posted on this since 2011 but now the revolution in therapy of leukemia approaches. The team of the University of Pennsylvania just published a new publication in NEJM. In short, they modify the patients’ lymphocytes to kill leukemic cells … and it works. The achieved the amazing 90% of remission rates in kids and adults with ALL – the patients with relapse after HSCT – the population with 100% mortality to leukemia which is normally not responsive anymore to chemotherapy. My question is what would happen if we apply this to the patients not after unsuccessful HSCT but instead any HSCT. The answer to this question might dramatically change the way we treat leukemia.

PS What about AML which is a major leukemia in adults? The same group published some promising results in animal model of AML.

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