Some of you might have heard about the hematopoietic stem cell transplants we did in diabetes. The biggest problem was that we could not replenish B cells that were already destroyed by immune system. Now there is a new method which combines the aproach of destroying the immune system and replenishing beta cells. First the stem cells are taken from fat tissue of a patient with diabetes then modified in lab to change into insulin secreting cells. In mean time immune system of patient is destroyed and after that patient recieves the modified cells – which start to secrete insulin….. And it works! At least according to this work: http://www.ncbi.nlm.nih.gov/pubmed/23893283
Are we looking at the future Nobel prize winners?
Time will tell. And I personally feel like making this treatment avaliable to Polish patients! (If it works…)
does it mean that, unlike previous hematopoietic stem cell transplant you did, this transplantation would not exclude nonhoneymoon patients?
This study was done in patients with no c-peptide secretion and few years history of diabetes – so potentially it is directed to all T1DM patients. However , as for now the results come only from one center so we have to wait for others to repeat this results.
Which center?
Some center in India – still they have not published followup data so I am not sure if this is legit